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Etain876
2 years ago

Ibuprofen doesn’t care. It just works everywhere.

Uniquorni
2 years ago

Pain exists only in the brain. There is also the ibuprofen. That means Ibuprofen just tells the brain: hey you’re wrong, there’s no pain.

DreifachSalchow
2 years ago
Reply to  Uniquorni

Ibuprofen does not work in the brain… It acts in the tissues in which prostaglandins are currently increasingly produced. And this happens where the pain or inflammation is, because prostaglandins are inflammatory mediators. Ibuprofen inhibits an enzyme that is involved in prostaglandin synthesis (cyclooxygenase I and II). And this enzyme inhibition occurs on the affected tissue, not in the brain. Opiates and opioids (like morphine, fentanyl…) act in the central nervous system.

tim75794
2 years ago

The active ingredient dissolves and spreads in the body.

tim75794
2 years ago
Reply to  Bea8015

The active ingredient affects your pain sensation, so it acts mainly in the brain.

Haffelpaff
2 years ago

ibus inhibit the general perception of pain, not specifically your acute pain.

DreifachSalchow
2 years ago
Reply to  Haffelpaff

No, another false answer, I’m crying :’) Don’t mean bad, but why do you write things you don’t even know if they’re voting? Your answer applies to opiates and opioids that modulate the perception of pain in the central nervous system, but NSAR as ibuprofen have a peripheral effect on the inflammatory tissues.

Haffelpaff
2 years ago

Ibuprofen inhibits the COX enzymes. This leads, among other things, to the loss of pain perception and pain sensation.

Haffelpaff
2 years ago

thanks to the

DreifachSalchow
2 years ago

With headaches, not the brain hurts, but the brain skins (the brain can not hurt as it does not have nodentities), or there are muscle pain (in case of injuries also bone pain). Pain of the cerebral skins or the neck muscles, as well as pain from the big toe, are transferred to the CNS only over a much shorter path. I.e.: noxic stimulus: outside the CNS, pain sensation: only arises in the CNS (in case of chronic pain it is another story). P.S. I must improve, the COX is also active in the hind horn of the spinal cord (in case of pain irritation) and in the hypothalamus (in the context of the fever development), so in fact Ibu also acts in the CNS. Nevertheless, I would not say that Ibu “generally inhibits the perception of pain” because it would be necessary to intervene in the descending pain-modulating system, as opioids do.

Haffelpaff
2 years ago

why does it help with headaches?

DreifachSalchow
2 years ago

The cycloocygenase inhibition inhibits prostaglandin synthesis, but this takes place peripherally in the inflamed tissues. And peripherally there is no pain sensation, which takes place only in the CNS, and there, for its modulation, would have to be taken into various transmitter metabolisms or into the endogenous pain inhibition of the CNS, as opioids do. The cyclooxygenase has no influence on this.