When viruses replicate in a host, do their DNAs remain exactly the same or does the host DNA have an influence?
If you get infected with a cold, coronavirus, etc., it means that viruses are multiplying inside you. Are the resulting new viruses genetically 100% identical to the original viruses?
I really mean 100,000,000,000%. And I don't mean mutations in the usual sense, but rather the question is whether host DNA has any influence, however small, on the "new" viruses.
Update: The answers so far are fine, but not exactly tailored to the question. Mutations, etc., aren't new to me; I'm simply interested in whether the DNA of the viruses produced in the host cell exactly matches the original virus or not. Or whether the host cell DNA has caused any change, however minimal.
(2 votes)
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A good question. I would say it does not change the mutations that arise, but it naturally changes the reproductive rate accordingly well to mutations adapted to the host.
Find out about mutation, at Corona you just need to read the daily press that new variants appear, what do you think they’re coming from?
I know all that, but my question is whether viruses change in principle in any reproduction, or their DNA, if they reproduce in a host, it does not always have to be mutation in the known sense. Or can one say that viruses generally mutate in every reproduction under the influence of the host DNA?
Because mutation is random, you can’t say that in general. Viruses must be relatively stable as they do not have their own metabolism, so they can’t repair anything. They would have died without mutations.
The host doesn’t change anything. This is the essence of virus reproduction.
Is that clear?
If it weren’t, the viruses would change constantly during each reproduction cycle. What is insane, because it’s about reproduction.
That mutations are added is logical. But you did not want to know that explicitly. But they are independent of the host cell.
There are always mutations, especially when a virus has skipped the species limit.
Doesn’t entirely answer my question, which is whether virus DNA changes in the reproduction in a host, though minimal.
Virologists see this. There are not rotations in every single replication, but they occur