Which seat on the bus is safest – front, back, middle, by the window or in the aisle, next to the restroom/central exit?

The farther one sits, the more protected one is in a frontal collision, which is the majority of heavy bus accidents as well as car accidents. If you are belted, the risk of injury is additionally minimized.

The fact that another vehicle drives into the rear or into the side of a bus and there are severely injured or even dead is very rare. The bus can also tip over, in this case it depends on the circumstances of the accident at which place the risk of injury is particularly high.

Even safer than on the bus, by the way you travel on the train and on the plane.