ByLara265
In point mutations, the DNA base sequence is the single strand of DNA complementary to the codogenic strand. This corresponds to mRNA with the exception of uracil. What does this mean, and why is the non-codogenic strand used? So, the gene mutations occur on the non-codogenic strand, but why?
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Weil der nicht codogene Strang in der Sequenz der mRNA entspricht und diese wird ja letztendlich am Ribosom in den Aminosäurecode übersetzt. Du kannst den nicht codogenen Strang also z. B. mit einer Code-Sonne 1:1 in die Abfolge der AS übersetzen und siehst so direkt, welche Auswirkung die Mutation auf das Protein hat.
Aber im Grunde genommen hast du natürlich recht, wenn im nicht codogenen Strang eine Mutation vorliegt, findet man beim Matritzenstrang an der komplementären Stelle die Mutation auch. Die müsste man dann aber eben erst in die mRNA umschreiben, um dann die Auswirkungen auf das Protein zu sehen. Da geht’s mit dem Sense-Strand einfach schneller.