Why does the drug MCP help so well?

Last year, I was diagnosed with a very rare tumor. It damaged my esophagus and metastasized to multiple organs. The esophageal condition improved with medication (pantoprazole and Suctabest).

But since the beginning of the year, I've been undergoing chemotherapy with tablets. Swallowing so many tablets (one of the medications is quite large) has caused my esophagus to get worse again. I often felt a tightness while eating and had to spit up mucus, sometimes for several hours.

In oncology

At the outpatient clinic where I go every two weeks, the doctors were a bit confused and didn't know what to do about it.

On Good Friday, I called the emergency medical service because I couldn't even eat yogurt without spitting up.

They then sent a doctor to my home. He prescribed me a really great medication, MCP. This medication is like a miracle cure. All my symptoms are gone. I asked my family doctor if the medication could repair my esophagus. She said no.

So why does the drug work so well?

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gutehackerrara
11 months ago

Hey.

I try to explain the mechanism of action of MCP (Metoclopramide).

So MCP is on the one hand a dopamine antagonist, i.e. it can bind to the same receptors as dopamine, and then blocks it for dopamine. This affects the nausea feeling as dopamine has an emetic effect (resolving vomitiness) when it binds to the receptors, but because they are “occupied” by MCP, the dopain cannot bind, conclusion: there is no nausea.

In addition, MCP can bind to the serotonin receptors, which then causes the peristaltic in the gastrointestinal tract to be excited and promotes the secretion of water and electrolytes. This in turn also helps to alleviate nausea/break.

Hope this helps:)