Under what reaction conditions does a hydrohalogenation reaction occur?
Hello everyone,
In theory, reactions like the addition of hydrogen bromide to alkenes are popular reactions for explaining electrophilic addition. However, there is virtually no literature online on the actual practical implementation of such a reaction, which I would be interested in.
For example, how would the synthesis proceed if 1-hexene were reacted with 48% aqueous hydrobromic acid to obtain 2-bromohexane? Especially with regard to temperature, mixing of potentially insoluble phases, and the use or omission of an additional solvent.
Thank you in advance for all answers!
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The simple answer: Without controlled conditions, you will get a wild mix of different products.
Aqueous goods will not only provide you with the brominated product, but also various alcohols resulting from the brominated products in the sense of an SN2 reaction. At the same time, you simply get brominated products plus your halohydrins.
That is exactly what would be interesting, what conditions it takes to achieve the desired product.
You can answer the question yourself 🙂 For example, you have to interrupt the reaction, reduce OH and H+ to a minimum. However, as aqueous HBr solution guarantees H+, you can exclude this option. Consequently, you can only direct HBr gas through a solution of witches. That would be an idea.