Protonation of amino acids – How does the Pka (=pks) value change?

Assumption: An amino acid with a COO group and an aromatic amino acid such as phenylalanine meet inside a protein, for example. As a result, COO is protonated to COOH. My question now is: Why is the pKa value increasing? I can't really explain it. When pKa=PH, half of a molecule is protonated and the…

"A substance has a pKa value of 7. At pH 4, approximately what percentage of this substance is in protonated form?"

Hello everyone, Chemistry is one of my biggest weaknesses, and here's a question I can't find an answer to anywhere. From the information provided, I can conclude that this is a weak acid. Since the pH is below 7, the solution is definitely acidic, but not strongly acidic. Using the formula pH = 1/2 *…