Incorrect storage of medications: Is effectiveness limited?

While on vacation, my companion meant well and packed all her medications in the refrigerator. Unfortunately, I only noticed it after three days. I've found that it's not that bad for most products. But what about Sedariston drops (St. John's wort, lemon balm, valerian) and Perenterol? I'm now worried that the Sedariston, in particular, is…

Is it possible that a medication (capsule) is less effective if I dissolve the contents in water?

I'm currently taking Perenterol and can't swallow capsules properly. The package insert says that if children can't swallow them, you can open the capsule and then dissolve it in water. I'm not a small child, but I do it anyway. Does it have a different effect? ​​It's possible that it's less effective.