You always read that most drugs are sold as salts, i.e., as hydrochloride or sulfate. But salts are ionic bonds, and the molecules of most drugs (except for psilocybin) are not (partially) charged, so how can a salt be formed?
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The salt or the charged form is easily obtained by using a base or acid. This presupposes that there are azide protons or atoms with electron pairs (nitrogen) which can absorb a proton.
It is important that at least part of the acid or base comes from a strong same. This is important precisely because the process of deprotination is not immediately reversed.
The salts have a much better solubility in water than the pure form.
In the body, the reversal may occur and the substance loses its polarity and can penetrate into the cells etc.
Many drugs (cocaine, morphine, heroin) are bases. Since they can be readily extracted and purified as salts, they are usually commercially available as such. In this case, it can be reconverted into the base form by treatment with sodium or the like. The basic properties of these substances (which have also been incorporated into them by the same name Alkaloides) follow from the presence of trivalent N atoms in the molecule — an additional H+ can always be added, just as in the NH3.
Although this may be the case in drugs (or often) ABER, in pharmacy this is more important for the solubility in the respective target organism. Note that many drugs have different pKs values due to their functional groups and therefore tend to absorb or release protons.
Had the subject in the lecture on medical chemistry 😉
well I know only with kokain as I had a lot to do with it in my lifetime
kokain the pure is always a salt in each case
at speed there are different forms but always dirty
in halucinogenic causes 2-cb is a salt in pure form
in lsd it is not possible to make it in salt form as well as in mushrooms
Cocaine we always traded as salt on the black market, but cocaine per se is a molecule and no salt and I wonder how this cocaine base in the salt looks just because the molecule is no base
Base -> crack, so it comes from the plant. Hydrochloride-> the cocaine that is scrubbed
yes
better it is. Did you have to go to jail?
I have no more of them
but a place in the holle
No, just for the sake of interest
if you want to kill/ lose your family.
Does it pay?
I’ll tell you who’s falling high so no
that business is so dirty I can only say
have paid for 1 kg 25k
100k costs that on the road and if you still stretch it, you make so much money that you will eventually get jerked off
I don’t care about it
are you still talking about it? (Write for a friend)
that 2 is very unlikely as I traded with it at 16 years:DD
pasta basica 😀
So either you have no idea of kokain or I have to learn more :DD
True it is called in the beginning, “pasta basica” because I thought it was basic
mostly is made with natron
because it is cheaper
ehm no crack is cooked with the hydrochloride
depends on either ammonia or sodium
in the lowlands cook it already kokain to crack
or make it already partially (cocain)
they have already been brought to the rubers because there are already many methods how to make it…