Mutual influence of St. John's wort and grapefruit?
Hello everyone,
How do the two substances affect each other ?
I know that both substances interact with medications.
I find the question of whether the effect of St. John's wort is strengthened or weakened or remains neutral more interesting.
Answers with pharmacological explanation if possible, if not then that's fine too.
Thanks for answers
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Actually, currants and grapefruit do not interact significantly. Both show numerous effects on various enzyme systems and their combination with other drugs is therefore critical to check.
The most important enzyme influenced by both is CYP3A4. St. John's wort induces (strengthens) its effects in the liver, grapefruit inhibits CYP3A4 in the intestine. St. John's Wort and Grapefruit therefore act opposite to the same enzyme, but focuses on two different locations.
Also the comparison with a specialist database (which doesn't matter here, because paid and actually I can get it according to. AGBs do not use privately) says: no relevant interaction between Grapefruit and St. John's Wort.
Neutral, I think…
Hey,
Thank you for your answer 🙂
Hi.
All right, thank you.