"lam" and "pam" – difference?

What does the different endings mean for benzodiazepines? How do benzodiazepines with the "lam" ending (e.g., midazolam, alprazolam, etc.) differ from those ending in "pam" (e.g., diazepam, lorazepam, bromazepam, etc.)?

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aalbtraum, UserMod Light

These are so-called characteristic silvers which are intended to indicate a specific belonging to an active substance family. This is explained in detail here:

Mysterium active substance names, https://www.deutsche-apotheker-zeitung.de/daz-az/2019/daz-41-2019/mysterium active substance names

Also interesting: International Free Name, https://de.wikipedia.org/wiki/International_Freename

As these names were derived, it is quite clear:

From al(pha) + p(henyl) + (t)r(i)azol(o) + -(azep)am.

→ https://en.wiktionary.org/wiki/alprazolam

From (benzo)diazep(ine) + am(ide).

→ https://en.wiktionary.org/wiki/diazepam

Rapunzel324
2 years ago

Benzodiazepines differ from the duration of action. (speed of metabolic degradation). Benzodiazepines have a short, medium or long-term effect. The potency and the half-life of the substance are important. Example: 10 mg of diazepam correspond to 0.5 mg of alprazolam. Tavor – Lorazepam has a very, high anxyolysis, i.e. strongly anxious. You write the ingredients. Tavor – Lorazepam. Valium – Diazepam. Dormicum – Midazolam etc.

Neugier4711
2 years ago

-azolam and -azepam are typical endings of neuroleptics whose differences however have little to do with the particular effect https://www.altmeyers.org/de/innere-medizin/benzodiazepine-5110

Rapunzel324
2 years ago
Reply to  Neugier4711

Benzodiazepines are completely different drugs than a neuroleptic. Examples of neuroleptics: Benpiridol, Fluspirilen, Melperon, Pipamperon, Haloperidol, Promethazine (Atosil) etc.

Rapunzel324
2 years ago
Reply to  Neugier4711

In the posted link, I do not read about neuroleptics, but only benzodiazepines. There is another relevant difference. With regular daily intake of benzodiazepines, the dependency potential does not begin after 2 weeks, in the case of a neuroleptic, such as promethazine-Atosil.

Neugier4711
2 years ago
Reply to  Rapunzel324

First of all, thank you for the correctness, but I do not understand the addition now, because Haloperidol makes a similar dependence to Lorazepam and Lormetazepam makes less dependent.

Rapunzel324
2 years ago

Here you can read this again, with respect to the dependency potentials. Sleeping agents, such as Zopiclon, also make dependent. https://link.springer.com/chapter/10.1007/978-3-662-55576-7_10

Rapunzel324
2 years ago

All benzodiazepines depend on when they are taken permanently and regularly. Therefore, benzos are an emergency medication and should only be accepted occasionally, unless the doctor prescribed it. Haloperidol is not a benzodiazepine, but a highly potent neuroleptic, with many side effects. Neuroleptics have no dependency potentials. https://www.bionity.com/en/lexikon/Haloperidol.html